Some people find it very difficult to tolerate THC in any way. The wide variety of reactions to cannabis with high THC content can be influenced by genetic factors. A common polymorphism (Sera Labs CBD Oil ) of a gene that encodes a cytochrome P450 enzyme in particular alters the way in which THC is metabolized, so it decomposes more slowly and remains active for longer, resulting in hypersensitivity to psychoactive effects of THC.
That may be one of the reasons why some people feel that high-THC cannabis is not pleasant, while millions of people smoke it simply to relax. This genetic variant exists between 20% of the population of Europe and the Middle East, which means that 1 in 5 Caucasians is adverse to THC. Less than 10% of Africans and less than 5% of Asians have this genetic variant.
THC vs. lung cancer. When smoking Sera Labs CBD Oil cannabis, the cytochrome P450 enzymes in the lungs convert the inhaled ash into potent carcinogens, including highly toxic polycyclic aromatic hydrocarbons (PAH). However, THC can provide protection against lung cancer by inhibiting the same metabolic enzymes that induce PAH.